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Certainty versus practicality: when is histologic proof needed prior to stereotactic ablative radiotherapy for solitary pulmonary nodules?

   
@article{TRO4846,
	author = {Andrew J. Arifin and Alexander V. Louie},
	title = {Certainty versus practicality: when is histologic proof needed prior to stereotactic ablative radiotherapy for solitary pulmonary nodules?},
	journal = {Therapeutic Radiology and Oncology},
	volume = {3},
	number = {0},
	year = {2019},
	keywords = {},
	abstract = {Stereotactic ablative radiotherapy (SABR) is a radiotherapy technique for treating early-stage non-small cell lung cancer (NSCLC), and is characterized by high dose per fraction, few fractions, and image-guided precision. Multiple studies have consistently demonstrated high rates of local control and a low incidence of serious adverse events, making it an attractive option for patients who are medically unfit for surgery. Although a biopsy is recommended for confirmation of the diagnosis prior to treatment, it is not without its risks. Herein we review the necessity of a biopsy prior to SABR for a solitary pulmonary nodule (SPN) suspicious for early-stage NSCLC. We examine malignancy prediction tools for assessing SPNs and scenarios in which forgoing a biopsy could be reasonable.},
	issn = {2616-2768},	url = {https://tro.amegroups.org/article/view/4846}
}