TY - JOUR AU - Yang, Shan-Jun AU - Pi, Chu-Ping AU - Chang, Tung-Hao AU - Liu, Mu-Tai AU - Huang, Chia-Chun AU - Hung, Li-Chung AU - Chou, Tsai-Wei AU - Lin, Jhen-Bin AU - Wang, Sheng-Hung PY - 2018 TI - Prognostic factors of axillary lymph node-positive patients in clinical stage II and III breast cancer after neoadjuvant chemotherapy JF - Therapeutic Radiology and Oncology; Vol 2 (September 2018): Therapeutic Radiology and Oncology Y2 - 2018 KW - N2 - Background: Surgery following neoadjuvant chemotherapy (NAC) is increasingly utilized for breast cancer treatment with respect to downstage and recurrent risk reduction. However, there are some uncertainties about the solutions of adjuvant radiotherapy (design of RT field and indication in low-risk patients) in patients after NAC, especially in clinically node-positive patients. The objective of this study is to identify the risk factors of loco-regional recurrence (LRR), relapse and overall survival (OS) regarding tumor response post-NAC in this institution. Methods: From 2007 to 2015, 90 patients with newly diagnosed clinical stage II (n=44) or III (n=46) breast cancer and pathological positive lymph nodes who received chemotherapy followed by breast conserving surgery or mastectomy, adjuvant radiotherapy, and some with adjuvant systemic therapy were identified. All of them received anthracycline-based or taxane-based chemotherapy, external beam radiotherapy and systemic treatment including target or hormone therapy if indicated. Methods: The patient characteristics included clinical T/N stage, pathologic T/N stage, response after NAC, tumor grade, surgical margin, the presence or absence of lymphovascular invasion and extracapsular extension, the total number of lymph nodes dissection, the positive lymph nodes ratio (pLNR), tumor biomarker status [estrogen receptor (ER)/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER-2)], and adjuvant chemotherapy/target therapy or not. Univariate and multivariate analyses for risks of loco-regional recurrence (LRR), relapse (any local, regional or distant recurrence), and overall survival (OS) and the survival curves of LRR and relapse were performed. Results: After a median follow-up duration of 62 months (7–125 months), the multivariate analysis for risks of LRR showed that the status of clinical lymph nodes (cN2: HR =6.07, P=0.046; cN3: HR =30.22, P=0.001), response subgroups (stable disease: HR =3.01, P=0.047; progressive disease: HR =10.76, P<0.001), and pLNR (67–100%: HR =4.32, P=0.025) have statistical significance. The multivariate analysis for risks of relapse also showed that the status of clinical lymph nodes (cN1 micro/N1: HR =3.97, P=0.037; cN2: HR =4.06, P=0.053; cN3: HR =10.39, P=0.005), response subgroups (progressive disease: HR =3.73, P=0.008) and pLNR (67–100%: HR =3.02, P=0.032) have statistical significance. The multivariate analysis of OS only showed the tumor biomarker status of triple-negative breast cancer (TNBC) (HR =3.04, P=0.048) has statistical significance. Conclusions: In this study, we recorded poor therapeutic response, advanced clinically positive lymph nodes, and higher proportional positivity of dissected lymph nodes showing poor outcome regarding the loco-regional control and relapse-free survival among patients with positive axillary lymph nodes after NAC. UR - https://tro.amegroups.org/article/view/4537